RoundsHospice and palliative care

Constipation in serious illness and with pain medicines

Why opioids and serious illness cause constipation, fluids, activity and a routine, when to ask before adding fiber, the kinds of laxatives a doctor may suggest, and when to call.

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Constipation is one of the most common and most overlooked problems in serious illness, especially for anyone taking opioid pain medicine. It’s uncomfortable, and left alone it can become serious. The good news is that it’s usually preventable.

Why it happens

Opioid pain medicines cause constipation, and so can eating and moving less.1 Tell the doctor or nurse as soon as it starts; early treatment helps prevent a blockage.1

Fluids, activity and a routine

Drinking 8 cups of water or clear liquids a day helps, if allowed; coffee, prune juice and warm drinks can help things move.1 Try to be active every day, even light exercise in a bed or chair.1 Eat at the same times each day and keep a record of bowel movements.1

Ask before adding fiber

Check with the doctor before adding fiber. For some people, especially those eating and drinking little, high-fiber foods and supplements make constipation worse.1

Medicines the doctor may suggest

Use only the treatments the doctor recommends.1 Options include stool softeners such as docusate, laxatives that pull water into the bowel such as polyethylene glycol, and laxatives that make the bowel move such as senna.1 Don’t use suppositories or enemas unless the doctor recommends them.1 Many people on opioids are started on a laxative at the same time.

What’s normal, and when to call

The goal is a bowel movement every day or every other day without hard stool or straining.1 Call if there are fewer than three bowel movements in a week, or severe belly pain or vomiting.1

Questions families ask

Does Dad’s pain medicine cause this?

Opioid pain medicines commonly cause constipation. Tell the doctor or nurse early.1

Should he eat more fiber?

Ask first. For some people fiber makes constipation worse.1

When do we call?

For fewer than three bowel movements in a week, severe belly pain or vomiting.1

Sources

Sources 1 reference
  1. National Cancer Institute, “Constipation and Cancer Treatment,” updated May 16, 2025. cancer.gov (opens in a new tab)

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